A high-temperature gas-cooled reactor (HTGR), is a nuclear reactor that uses a graphite moderator with a once-through uranium fuel cycle. The HTGR is a type of high-temperature reactor (HTR) that can conceptually have an outlet temperature of 750 °C (1,380 °F). The reactor core can be either a "prismatic block" (reminiscent of a conventional reactor core) or a "pebble-bed" core. The high temperatures enable applications such as process heat or hydrogen production via the thermochemical sulfur–iodine cycle.

The HTR is the predecessor of the Very-high-temperature reactor (VHTR), one of the future Generation IV reactor-models, which initially would work with temperatures of 750 to 950 °C.